home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410b.zip
/
M94A0262.TXT
< prev
next >
Wrap
Text File
|
1994-10-08
|
2KB
|
37 lines
Document 0262
DOCN M94A0262
TI Development of clinical disease in cats experimentally infected with
feline immunodeficiency virus.
DT 9412
AU English RV; Nelson P; Johnson CM; Nasisse M; Tompkins WA; Tompkins MB;
Department of Microbiology, Pathology, and Parasitology, College; of
Veterinary Medicine, North Carolina State University, Raleigh; 27606.
SO J Infect Dis. 1994 Sep;170(3):543-52. Unique Identifier : AIDSLINE
MED/94358486
AB Cats naturally infected with feline immunodeficiency virus (FIV) develop
an AIDS-like syndrome whereas experimentally infected cats do not. To
investigate the role of cofactors in the development of this disease in
cats, 7 specific pathogen-free (SPF) and 12 random-source (RS) cats were
infected with FIV. Over 4 years, infected cats developed similar
phenotypic and functional immune abnormalities characterized by early
and chronic inversion of CD4+:CD8+ cell ratios and significantly
decreased mitogen responses compared with controls. Beginning 18-24
months after infection, 10 RS cats developed chronic clinical disease
typical of feline AIDS, including stomatitis and recurrent upper
respiratory disease; 4 SPF cats also developed chronic clinical disease,
2 with neurologic disease and 2 with B cell lymphomas. Thus, immunologic
background is important in the type of disease that develops in cats
infected with FIV, and FIV represents a promising animal model for
studying the immunopathogenesis of AIDS in humans.
DE Animal Antibody Formation B-Lymphocytes/IMMUNOLOGY Blotting, Southern
Cats CD4-CD8 Ratio Feline Acquired Immunodeficiency
Syndrome/COMPLICATIONS/ IMMUNOLOGY/*PHYSIOPATHOLOGY Female
Immunodeficiency Virus, Feline/ISOLATION & PURIF/*PATHOGENICITY
Lymphocyte Subsets/*IMMUNOLOGY *Lymphocyte Transformation Polymerase
Chain Reaction Support, U.S. Gov't, P.H.S. Time Factors JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).